Wang Lab Publications

Kloth AD, Badura A, Li a, Cherskov A, Connolly SG, Giovannucci A, Bangash MA, Grasselli G, Peñagarikano O, Piochon C, Tsai PT, Geschwind DH, Hansel C, Sahin M, Takumi T, Worley PF, Wang SSH (2015) Cerebellar associative sensory learning defects in five mouse autism models. eLife, doi: 10.7554/eLife.06085. [Link to journal] [PubMed]

Badura A, Sun XR, Giovannucci A, Lynch L, Wang SS-H. (2014) Fast calcium sensor proteins for monitoring neural activity. Neurophoton, 1: 025008. doi:10.1117/1.NPh.1.2.025008. [Link to journal] [PDF] [PubMed]

Wang SS-H, Kloth AD, and Badura A (2014) The cerebellum, sensitive periods, and autism (Perspective). Neuron, 83:518-532. doi:10.1016/j.neuron.2014.07/016 [Link to journal] [PDF]

*Najafi F, *Giovannucci A, Wang SS-H, Medina JF (2014) Sensory-driven enhancement of calcium signals in individual Purkinje cell dendrites of awake mice. Cell Reports, 6:792-798. doi: 10.1016/j.celrep.2014.02.001. [PDF] [Pub Med]

Post Publication Note: We thank Charlotte Arlt, Michael Häusser, and Christian Wilms for advice on the virus combination for the preferential expression of GCaMP in Purkinje cells.

Shi DD, Trigo FF, Semmelhack MF, Wang SS-H (2014) Synthesis and biological properties of bis-CNB-GABA, a photoactivatable neurotransmitter with low receptor interference and chemical two-photon uncaging properties. Journal of the American Chemical Society, 36:1976-1981. doi:10.1021/ja411082f [PDF] [Link to journal] [Pub Med]

Wang SS-H and Campbell BC (2013) Mr. Bayes Goes to Washington. Science 339:758-759. doi: 10.1126/science.1232290. [Summary] [Full Text]

*X.R. Sun, *A. Badura, D. A. Pacheco, L.A. Lynch, E.R. Schneider, M.P. Taylor, I.B. Hogue, L.W. Enquist, M. Murthy, S.S.-H. Wang (2013) Fast GCaMPs for improved tracking of neuronal activity. Nature Communications, 42167:1-10. doi:10.1038/ncomms3170. [Link to journal] [PDF]

I. Ozden, H.M. Lee, M.R. Sullivan, and S.S.-H. Wang (2009): Identification and clustering of event patterns from in vivo multiphoton optical recordings of neuronal ensembles. Journal of Neurophysiology, 29:10463-10473. [Link to journal] [PubMed] [PDF]

T.M. Hoogland*, B. Kuhn*, W. Göbel, W. Huang, J. Nakai, F. Helmchen, S.J. Flint, and S.S.-H. Wang (2009): Radially expanding transglial calcium waves in the intact cerebellum. Proc. Natl. Acad. Sci. USA, 106:3496-3501. [Link to journal] [PubMed] [PDF]

D.V. Sarkisov and S.S.-H. Wang (2008): Order-dependent coincidence detection in cerebellar Purkinje neurons at the inositol triphosphate receptor. Journal of Neuroscience, 28:133-142. [PDF] [Link to journal] [Supplementary Information]

D.V. Sarkisov, S.E. Gelber, J.W. Walker, and S.S.-H. Wang (2007): Synapse-specificity of calcium release probed by chemical two-photon uncaging of IP3. Journal of Biological Chemistry, 282:25517-25526. [PDF] [Link to journal]

D.V. Sarkisov and S.S.-H. Wang (2007): Combining uncaging techniques with patch-clamp recording and optical physiology. Patch-clamp analysis, 2nd edition. Editor: W.Walz. Humana Press. [PDF] [Amazon]

D.V. Sarkisov and S.S.-H. Wang (2006): Alignment and calibration of a focal neurotransmitter uncaging system. Nature Protocols, 1:828-832. [PDF] [Link to journal]

S.S.-H. Wang, W. Denk and M. Häusser (2000): Coincidence detection in single dendritic spines mediated by calcium release. Nature Neuroscience, 3(12):1266-1273. [PDF] [Link to journal] [PubMed] [Faculty of 1000 recommendation]

S.S.-H. Wang, L. Khiroug and G.J. Augustine (2000): Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate. Proc. Natl. Acad. Sci., 97:8635-8640. [Link to journal] [PubMed]


 

Kloth AD, Badura A, Li a, Cherskov A, Connolly SG, Giovannucci A, Bangash MA, Grasselli G, Peñagarikano O, Piochon C, Tsai PT, Geschwind DH, Hansel C, Sahin M, Takumi T, Worley PF, Wang SSH (2015) Cerebellar associative sensory learning defects in five mouse autism models. eLife, doi: 10.7554/eLife.06085. [Link to journal] [PubMed]

Badura A, Sun XR, Giovannucci A, Lynch L, Wang SS-H. (2014) Fast calcium sensor proteins for monitoring neural activity. Neurophoton, 1: 025008. doi:10.1117/1.NPh.1.2.025008. [Link to journal] [PDF] [PubMed]

Wang SS-H, Kloth AD, and Badura A (2014) The cerebellum, sensitive periods, and autism (Perspective). Neuron, 83:518-532. doi:10.1016/j.neuron.2014.07/016 [Link to journal] [PDF]

*Najafi F, *Giovannucci A, Wang SS-H, Medina JF (2014) Sensory-driven enhancement of calcium signals in individual Purkinje cell dendrites of awake mice. Cell Reports, 6:792-798. doi: 10.1016/j.celrep.2014.02.001. [PDF] [Pub Med]

Post Publication Note: We thank Charlotte Arlt, Michael Häusser, and Christian Wilms for advice on the virus combination for the preferential expression of GCaMP in Purkinje cells.

Shi DD, Trigo FF, Semmelhack MF, Wang SS-H (2014) Synthesis and biological properties of bis-CNB-GABA, a photoactivatable neurotransmitter with low receptor interference and chemical two-photon uncaging properties. Journal of the American Chemical Society, 36:1976-1981. doi:10.1021/ja411082f [PDF] [Link to journal] [Pub Med]

Wang SS-H and Campbell BC (2013) Mr. Bayes Goes to Washington. Science 339:758-759. doi: 10.1126/science.1232290. [Summary] [Full Text]

*X.R. Sun, *A. Badura, D. A. Pacheco, L.A. Lynch, E.R. Schneider, M.P. Taylor, I.B. Hogue, L.W. Enquist, M. Murthy, S.S.-H. Wang (2013) Fast GCaMPs for improved tracking of neuronal activity. Nature Communications, 42167:1-10. doi:10.1038/ncomms3170. [Link to journal] [PDF]

I. Ozden, H.M. Lee, M.R. Sullivan, and S.S.-H. Wang (2009): Identification and clustering of event patterns from in vivo multiphoton optical recordings of neuronal ensembles. Journal of Neurophysiology, 29:10463-10473. [Link to journal] [PubMed] [PDF]

T.M. Hoogland*, B. Kuhn*, W. Göbel, W. Huang, J. Nakai, F. Helmchen, S.J. Flint, and S.S.-H. Wang (2009): Radially expanding transglial calcium waves in the intact cerebellum. Proc. Natl. Acad. Sci. USA, 106:3496-3501. [Link to journal] [PubMed] [PDF]

D.V. Sarkisov and S.S.-H. Wang (2008): Order-dependent coincidence detection in cerebellar Purkinje neurons at the inositol triphosphate receptor. Journal of Neuroscience, 28:133-142. [PDF] [Link to journal] [Supplementary Information]

D.V. Sarkisov, S.E. Gelber, J.W. Walker, and S.S.-H. Wang (2007): Synapse-specificity of calcium release probed by chemical two-photon uncaging of IP3. Journal of Biological Chemistry, 282:25517-25526. [PDF] [Link to journal]

D.V. Sarkisov and S.S.-H. Wang (2007): Combining uncaging techniques with patch-clamp recording and optical physiology. Patch-clamp analysis, 2nd edition. Editor: W.Walz. Humana Press. [PDF] [Amazon]

D.V. Sarkisov and S.S.-H. Wang (2006): Alignment and calibration of a focal neurotransmitter uncaging system. Nature Protocols, 1:828-832. [PDF] [Link to journal]

S.S.-H. Wang, W. Denk and M. Häusser (2000): Coincidence detection in single dendritic spines mediated by calcium release. Nature Neuroscience, 3(12):1266-1273. [PDF] [Link to journal] [PubMed] [Faculty of 1000 recommendation]

S.S.-H. Wang, L. Khiroug and G.J. Augustine (2000): Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate. Proc. Natl. Acad. Sci., 97:8635-8640. [Link to journal] [PubMed]


 

Synaptic learning rules and dendritic physiology

D.H. O’Connor, G.M. Wittenberg, and S.S.-H. Wang (2007): Timing and contributions of pre-synaptic and post-synaptic parameter changes during unitary plasticity events at CA3-CA1 synapses. Synapse, 61:664-678. [PDF] [Link to journal]

G.M. Wittenberg and S.S.-H. Wang (2006): Malleability of spike-timing-dependent plasticity at the CA3-CA1 synapse. Journal of Neuroscience, 26:6610-6617, doi:10.1523/JNEUROSCI.5388-05.2006. [PDF] [Link to journal] [Technical Note]

D.H. O’Connor, G.M. Wittenberg, and S.S.-H. Wang (2005): Dissection of bidirectional synaptic plasticity into saturable unidirectional processes. Journal of Neurophysiology, 94:1565-1573, doi:10.1152/jn.00047.2005. [PDF] [Link to journal] [PubMed]

D.H. O’Connor, G.M. Wittenberg, and S.S.-H. Wang (2005): Graded bidirectional synaptic plasticity is composed of switch-like unitary events. Proc. Natl. Acad. Sci. USA, 102(27):9679-9684. [PDF (500k)] [Figures at high resolution] [Link to journal] [PubMed]

S.S.-H. Wang and G. Major (2003): Integrating over time with dendritic wave-fronts. Nature Neuroscience, 6(9):906-908. [PDF] [Link to journal] [PubMed]

Brain scaling and evolution

Wang S. (2009) Journal club. A neuroscientist explores the energy efficiency of the brain. Nature, 461:851. [PDF] [Link to journal] [PubMed]

S.-H. Wang, J.R. Shultz, M.J. Burish, K.H. Harrison, P.R. Hof, L.C. Towns, M.W. Wagers, and K.D. Wyatt (2008): Functional trade-offs in white matter axonal scaling. Journal of Neuroscience, 28:4047-4056. [Preprint[Link to journal]

G.M. Wittenberg and S.S.-H. Wang (2007): Evolution and scaling of dendrites. Dendrites, 2nd edition. Editors: M. Häusser, N. Spruston and G. Stuart. Oxford University Press. [PDF] [OU Press]

S. Shoham, D.H. O'Connor, R. Segev (2006): How silent is the brain: is there a "dark matter" problem in neuroscience? Journal of Comparative Physiology, 192:777-784. [PDF] [Link to journal] [PubMed]

K.D. Wyatt, P. Tanapat, and S.S.-H.Wang (2005): Speed limits in the cerebellum: constraints from myelinated and unmyelinated parallel fibers. European Journal of Neuroscience, 21:2285-2290. [PDF] [Link to journal] [PubMed]

M.J. Burish, H.Y. Kueh and S.S-.H. Wang (2004): Brain architecture and social complexity in modern and ancient birds. Brain, Behavior and Evolution, 63:107-124. [PDF] [Link to journal] [PubMed]

S.S.-H. Wang, P.P. Mitra and D.A. Clark (2002): Brain evolution (Communications arising): How did brains evolve?  Nature, 415:135. [PDF] [PubMed]

J. DeFelipe, G.N. Elston, I. Fujita, J. Fuster, K.H. Harrison, P.R. Hof, Y. Kawaguachi, K.A.C. Martin, K.S. Rockland, A.M. Thomson, S.S.-H. Wang, E.L. White, and R. Yuste (2002) Neocortical circuits: Evolutionary aspects and specificity versus non-specificity of synaptic connections. Remarks, main conclusions and general comments and discussion. Journal of Neurocytology, 30:387-416.

K.H. Harrison, P.R. Hof, and S.S.-H. Wang (2002): Scaling laws in the mammalian neocortex: does form provide clues to function? Journal of Neurocytology, 30:289-298. [PDF] [Link to journal] [PubMed]

D.A. Clark, P.P. Mitra and S.S.-H. Wang (2001): Scalable architecture in mammalian brains.  Nature, 411:189-193 (also see News and Views). [PDF] [Link to journal] [PubMed]

Optical methods

Wang SSH and Campbell BC. (2013) Mr. Bayes Goes to Washington. Science 339:758-759. doi: 10.1126/science.1232290.Summary | Full Text

A.E. Granstedt, M.L. Szpara, B. Kuhn, S.S.-H. Wang, and L.W. Enquist (2009) Fluorescence-based monitoring of activity in virally traced neural circuits. PLoS ONE, 9:e6923. [Link to journal] [PDF]

M.R. Sullivan, A. Nimmerjahn, D.V. Sarkisov, F. Helmchen, and S.S.-H. Wang (2005): In vivo calcium imaging of circuit activity in cerebellar cortex. Journal of Neurophysiology, 94:1636-1644, doi:10.1152/jn.01013.2004. [Link to journal] [PubMed] [movie 1] [movie 2] [movie 3]

S. Shoham*, D.H. O’Connor*, D.V. Sarkisov, and S.S.-H. Wang (2005): Rapid neurotransmitter uncaging in spatially defined patterns. Nature Methods, 2:837-843. [PDF]

S.M. Thompson, J.P.Y. Kao, R.H. Kramer, K.E. Poskanzer, R.A. Silver, D. Digregorio, and S.S.-H. Wang (2005) Flashy science: controlling neural function with light (Mini-symposium review). Journal of Neuroscience, 25:10358-10365. [Link to journal] [PubMed]

General interest

Sam Wang (2009): Postcards from the Brain. Physics World, July 2009: 37-39. [PDF]

Sandra Aamodt and Sam Wang. Welcome To Your Brain: Why You Lose Your Keys But Never Forget How To Drive And Other Mysteries Of Everyday Life. Bloomsbury USA. Publication date March 2008. [Welcome To Your Brain website]

Sam Wang and Sandra Aamodt. “A Vast Left-Handed Conspiracy.” Washington Post, July 6, 2008. [Washington Post]

Sam Wang and Sandra Aamodt. “Your Brain Lies to You.” New York Times, June 27, 2008. [New York Times]

Sam Wang. “Autism myth lives on.” USA Today, April 16, 2008. [USA Today]

Sandra Aamodt and Sam Wang. “Tighten Your Belt, Strengthen Your Mind.” New York Times, April 2, 2008. [New York Times]

Sandra Aamodt and Sam Wang. “Exercise On The Brain.” New York Times, November 8, 2007. [New York Times 

Sam Wang. "Donald Trump Is Not the Frontrunner. Smarter Polls Would Prove It." New Republic, Election 2016, July 20, 2015. [New Republic]

Before Princeton

Synaptic plasticity and neuronal function

G.J. Augustine, E.A. Finch, and S.S.-H. Wang (1998): The spatial range of dendritic signals for cerebellar long-term depression: studies with local photolysis of caged compounds.  In Integrative aspects of Ca2+ signalling. (Ed. A. Verkhratsky and E.C. Toescu).  Plenum Press.

DeBello, W.M., V. O'Connor, T. Dresbach, S.W. Whiteheart, S.S.-H. Wang, F.E. Schweizer, H. Betz, J.E. Rothman and G.J. Augustine (1995): SNAP-mediated protein-protein interactions essential for neurotransmitter release.  Nature, 373:626-630. [PDF] [Link to journal] [PubMed] [PDF] [Link to journal] [PubMed]

G.J. Augustine, H. Betz, K. Bommert, M.P. Charlton, W.M. DeBello, T. Dresbach, J.M. Hunt, V. O’Connor, F.E. Schweizer, S.S.-H. Wang, and S.W. Whiteheart (1996): Molecular mechanisms of neurotransmitter secretion: functional studies at the squid giant synapse. In Basic neuroscience in invertebrates. (Ed. H. Koike, Y. Kidokoro, K. Takahashi, T. Kanaseki)  Japan Scientific Societies Press.

M.E. Burns, S.A. Beushausen, G.J. Chin, D. Tang, W.M. DeBello, T. Dresbach, V. O'Connor, F.E. Schweizer, S.S.-H. Wang, S.W. Whiteheart, H. Betz, J.E. Rothman, and G.J. Augustine (1995): Proteins involved in synaptic vesicle docking and fusion.Cold Spring Harb. Symp. Quant. Biol. 60:337-348.

Optical and other methods

T. Furuta, S.S.-H. Wang, J.L. Dantzker, T.M. Dore, W.J. Bybee, E.M. Callaway, W. Denk and R.Y. Tsien (1999): Brominated 7-hydroxycoumarin-4-ylmethyls: novel photolabile protecting groups with biologically useful cross-sections for two photon photolysis. Proc. Natl. Acad. Sci., 96(4):1193-1200. 

G.J. Augustine, D.L. Pettit, and S.S.-H. Wang (1999): Spatially resolved flash photolysis via chemical two-photon uncaging. In Imaging: a laboratory manual. (Eds. R. Yuste, F. Lanni, A. Konnerth) Cold Spring Harbor Press.

D.L. Pettit*, S.S.-H. Wang*, K.R. Gee and G.J. Augustine (1997): Chemical two-photon uncaging: a novel approach to mapping glutamate receptors. Neuron, 19:465-471.
*The first two authors contributed equally to this work.[PDF] [Link to journal] [PubMed]

S.S.-H. Wang and G.J. Augustine (1995): Confocal imaging and local photolysis of caged compounds: dual probes of synaptic function. Neuron, 15:755-760. [PDF] [PubMed]

S.S.-H. Wang, C.A. Mathes, and S.H. Thompson (1993): Membrane toxicity of the protein kinase C inhibitor calphostin A by a free-radical mechanism. Neuroscience Letters, 157:25-28. (published in error a second time as 156:145–148) [PDF] [Link to journal] [PubMed]

S.S.-H. Wang and S. Thompson (1992): A-type potassium channel clusters revealed using a new statistical analysis of loose patch data. Biophysical Journal, 63:1018-1025. [PDF] [Link to journal]

IP3, calcium signaling, and intracellular calcium wave propagation

S.S.-H. Wang and G.J. Augustine (1999): Calcium signaling in neurons: a case study in cellular compartmentalization.  In Calcium as a cellular regulator. (Ed. E. Carafoli and C.B. Klee) Oxford University Press, pp. 545-566.

R. Kupferman, P.P. Mitra, P.C. Hohenberg and S.S.-H. Wang (1997): Analytical calculation of intracellular calcium wave characteristics.  Biophysical Journal, 72:2430-2444. [PDF] [Link to journal] [PubMed]

S.S.-H. Wang and S.H. Thompson (1995): Local positive feedback by calcium in the propagation of intracellular calcium waves. Biophysical Journal, 69:1683-1697. [PDF] [Link to journal] [PubMed]

S.S.-H. Wang, A.A. Alousi and S.H. Thompson (1995): The lifetime of inositol 1,4,5-trisphosphate in single cells. Journal of General Physiology,105:149-171. [PDF] [PubMed]

S.S.-H. Wang and S.H. Thompson (1994): Measurement of changes in muscarinic and histaminergic receptor density in single neuroblastoma cells using calcium release desensitization.  Cell Calcium, 15:483-496. [PDF] [PubMed]

S.S.-H. Wang (1993): Modeling the apparent diffusion constant of calcium ions emanating from a channel: implications for calcium wave propagation. Biological Bulletin, 185:297-298. [PDF]

C.A. Mathes, S.S.-H. Wang, H.M. Vargas, and S.H. Thompson (1992): Intracellular calcium release in N1E-115 neuroblastoma cells is mediated by the M1 muscarinic receptor subtype and is antagonized by McN-A-343.  Brain Research, 585:307-310. [PDF] [Link to journal] [PubMed]

Neuroethology

A.E. Schivell, S.S.-H. Wang, and S.H. Thompson (1997): Behavioral modes arise from a random process in the nudibranch Melibe.  Biological Bulletin, 192(3):418-425. [PDF] [Link to journal]

Serotonin receptors

S.J. Peroutka, A. Hamik, M.A. Harrington, C.A. Mathis, P.A. Pierce, and S.S.-H. Wang (1988): R-2,5-dimethoxy-4-77bromoamphetamine [77R(–)DOB] labels a novel 5-hy-droxytryptamine binding site in brain membranes.  Molecular Pharmacology, 34:537-542. [PDF] [Link to journal] [PubMed]

S.S.-H. Wang, C.A. Mathis, and S.J. Peroutka (1988): R-2,5-Dimethoxy-4-77bromoamphetamine (77Br-R(–) DOB): a novel radioligand which labels a 5-HT binding site subtype.  Psychopharmacology, 94:431-432. [PDF1] [PDF2] [PubMed]

S.S.-H. Wang, G.A. Ricaurte, and S.J. Peroutka (1987): 3H-3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") interactions with brain membranes and glass fiber filter paper. European Journal of Pharmacology 138:439-443. [PDF] [Link to journal] [PubMed]

S.S. Wang and S.J. Peroutka (1989): Historical perspectives. In The Serotonin Receptors. (Ed. E. Sanders-Bush). Humana Press, pp. 3-20.

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Facts, myths and useful tips about your brain
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