Toettcher Lab Publications


Johnson HE, Goyal Y, Pannucci NL, Schupbach T, Shvartsman SY, Toettcher JE.
The spatiotemporal limits of developmental Erk signaling.
(2017) Developmental Cell 40(2): 185-192. | Pubmed

Shin Y, Berry J, Pannucci NL, Haataja MP, Toettcher JE, Brangwynne CP.
Spatiotemporal control of intracellular phase transitions using light-activated optoDroplets.
(2017) Cell 168(1): advance online publication. | Pubmed

Diner BA, Lum KK, Toettcher JE, Cristea IM.
Viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during Herpesvirus infection.
(2016) mBio 7.6: e0155-16. | Pubmed

Gordley RM, Williams RE, Bashor CJ, Toettcher JE, Yan S, Lim WA.
Engineering dynamical control of cell fate switching using synthetic phospho-regulons.
(2016) Proc Nat Acad Sci 113(47): 13528-13533. | Pubmed

Johson HE, Toettcher JE.
The duty of an intracellular signal: illuminating calcium’s role in transcriptional control.
(2016) Cell Systems 2: 223-224. | Pubmed

Hoeller O, Toettcher JE, Cai H, Sun Y, Huang C-H, Freyre M, Zhao M, Devreotes PN, Weiner OD.
Gβ regulates coupling between actin oscillators for cell polarity and directional migration.
(2016) PLoS Biol 14: e1002381. | Pubmed

Toettcher JE, Weiner OD, Lim WA.
Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module.
(2013) Cell 155: 1422-34. | Pubmed

Toettcher JE, Gong D, Lim WA, Weiner OD.
Light-based feedback for controlling intracellular signaling dynamics.
(2011) Nat Methods. 8: 837-839. | Pubmed

Toettcher JE, Voigt CA, Weiner OD, Lim WA.
The promise of optogenetics in cell biology: interrogating molecular circuits in space and time.
(2011) Nat Methods. 1: 35-38. | Pubmed

Toettcher JE, Gong D, Lim WA, Weiner OD.
Light control of plasma membrane recruitment using the Phy-PIF system.
(2011) Methods Enzymol. 497: 409-23. | Pubmed

Toettcher JE, Castillo A, Tidor B, White JK.
Oscillator sensitivity analysis in the presence of hidden conservation constraints.
(2011) Proceedings of the 48th IEEE Design Automation Conference 806-811.

Toettcher JE, Apgar JF, Castillo AR, Tidor B, White JK.
Recycling circuit simulation techniques for mass-action biochemical kinetics.
(2011) Advanced Simulation and Verification of Electronic and Biological Systems, 115-136.

Toettcher JE, Mock C, Batchelor E, Loewer A, Lahav G.
A synthetic-natural hybrid oscillator in human cells.
(2010) Proc Natl Acad Sci. 107: 17047-52. | Pubmed

Toettcher JE, Loewer A, Ostheimer GJ, Yaffe MB, Tidor B, Lahav G.
Distinct mechanisms act in concert to mediate cell cycle arrest.
(2009) Proc Natl Acad Sci. 106: 785-90. | Pubmed

Apgar JF, Toettcher JE, Endy D, White FM, Tidor B.
Stimulus design for model selection and validation in cell signaling.
(2008) PLoS Comput Biol. 4: e30. | Pubmed

Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV. X
Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity.
(2008) Cell 122: 169-82. | Pubmed