Stock Lab Publications



Recent Publications

Stock JB1, Zhang S.
The biochemistry of memory.
Curr Biol. 2013 Sep 9;23(17):R741-5. doi: 10.1016/j.cub.2013.08.011.
Lee KW1, Im JY, Woo JM, Grosso H, Kim YS, Cristovao AC, Sonsalla PK, Schuster DS, Jalbut MM, Fernandez JR, Voronkov M, Junn E, Braithwaite SP, Stock JB, Mouradian MM.
Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease.
Neurotherapeutics. 2013 Jan;10(1):143-53. doi: 10.1007/s13311-012-0165-2.


Fernandéz JR1, Rouzard K, Voronkov M, Feng X, Stock JB, Stock M, Gordon JS, Shroot B, Christensen MS, Pérez E.
SIG1273: a new cosmetic functional ingredient to reduce blemishes and Propionibacterium acnes in acne prone skin.
J Cosmet Dermatol. 2012 Dec;11(4):272-8. doi: 10.1111/jocd.12002.
Braithwaite SP, Stock JB, Mouradian MM.
α-Synuclein phosphorylation as a therapeutic target in Parkinson's disease.
Rev Neurosci. 2012 Mar 21;23(2):191-8. 
Braithwaite SP, Voronkov M, Stock JB, Mouradian MM.
Targeting phosphatases as the next generation of disease modifying therapeutics for Parkinson's disease.
Neurochem Int. 2012 Feb 8. [Epub ahead of print] 
Braithwaite SP, Stock JB, Lombroso PJ, Nairn AC.
Protein phosphatases and Alzheimer's disease.
Prog Mol Biol Transl Sci. 2012;106:343-79. 

Lee KW, Chen W, Junn E, Im JY, Grosso H, Sonsalla PK, Feng X, Ray N, Fernandez JR, Chao Y, Masliah E, Voronkov M, Braithwaite SP, Stock JB, Mouradian MM.
Enhanced phosphatase activity attenuates α-Synucleinopathy in a mouse model.
J Neurosci. 2011 May 11;31(19):6963-71. PubMed PMID: 21562258. 

Voronkov M, Braithwaite SP, Stock JB.
Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease.
Future Med Chem. 2011 May;3(7):821-33. Review. PubMed PMID: 21644827; PubMed Central PMCID: PMC3292348. 
Li Z, Stock JB.
Protein carboxyl methylation and the biochemistry of memory.
Biol Chem. 2009 Nov;390(11):1087-96. Review.
PubMed PMID: 19747079. 

Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y.
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Cell. 2008 Apr 4;133(1):154-63.
PubMed PMID: 18394995. 
Gordon JS, Wolanin PM, Gonzalez AV, Fela DA, Sarngadharan G, Rouzard K, Perez E, Stock JB, Stock MB.
Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site.
J Invest Dermatol. 2008 Mar;128(3):643-54. Epub 2007 Sep 20.
Baker MD, Stock JB.
Signal transduction: networks and integrated circuits in bacterial cognition.
Curr Biol. 2007 Dec 4;17(23):R1021-4.

Chen Y, McQuade KJ, Guan XJ, Thomason PA, Wert MS, Stock JB, Cox EC.
Isoprenylcysteine carboxy methylation is essential for development in Dictyostelium discoideum.
Mol Biol Cell. 2007 Oct;18(10):4106-18. Epub 2007 Aug 15. 
Chen Y, Xu Y, Bao Q, Xing Y, Li Z, Lin Z, Stock JB, Jeffrey PD, Shi Y.
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.
Nat Struct Mol Biol. 2007 Jun;14(6):527-34. Epub 2007 May 27. 
Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y.
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.
Cell. 2006 Oct 20;127(2):341-53. 
Wolanin PM, Baker MD, Francis NR, Thomas DR, DeRosier DJ, Stock JB.
Self-assembly of receptor/signaling complexes in bacterial chemotaxis.
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14313-8. Epub 2006 Sep 14. 
Chao Y, Xing Y, Chen Y, Xu Y, Lin Z, Li Z, Jeffrey PD, Stock JB, Shi Y.
Structure and mechanism of the phosphotyrosyl phosphatase activator.
Mol Cell. 2006 Aug;23(4):535-46. 
Thomason PA, Sawai S, Stock JB, Cox EC.
The histidine kinase homologue DhkK/Sombrero controls morphogenesis in Dictyostelium.
Dev Biol. 2006 Apr 15;292(2):358-70. Epub 2006 Feb 13. 
Baker MD, Wolanin PM, Stock JB.
Systems biology of bacterial chemotaxis.
Curr Opin Microbiol. 2006 Apr;9(2):187-92. Epub 2006 Mar 9. 
Baker MD, Wolanin PM, Stock JB.
Signal transduction in bacterial chemotaxis.
Bioessays. 2006 Jan;28(1):9-22. 
Francis NR, Wolanin PM, Stock JB, Derosier DJ, Thomas DR.
Three-dimensional structure and organization of a receptor/signaling complex.
Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17480-5. Epub 2004 Nov 30. 
Webre DJ, Wolanin PM, Stock JB.
Modulated receptor interactions in bacterial transmembrane signaling.
Trends Cell Biol. 2004 Sep;14(9):478-82. 
Wolanin PM, Stock JB.
Bacterial chemosensing: cooperative molecular logic.
Curr Biol. 2004 Jun 22;14(12):R486-7. 
Wolanin PM, Webre DJ, Stock JB.
Mechanism of phosphatase activity in the chemotaxis response regulator CheY.
Biochemistry. 2003 Dec 2;42(47):14075-82.
Park S, Wolanin PM, Yuzbashyan EA, Lin H, Darnton NC, Stock JB, Silberzan P, Austin R.
Influence of topology on bacterial social interaction.
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13910-5. Epub 2003 Nov 17. 
Park S, Wolanin PM, Yuzbashyan EA, Silberzan P, Stock JB, Austin RH.
Motion to form a quorum.
Science. 2003 Jul 11;301(5630):188. 
Napper S, Wolanin PM, Webre DJ, Kindrachuk J, Waygood B, Stock JB.
Intramolecular rearrangements as a consequence of the dephosphorylation of phosphoaspartate residues in proteins.
FEBS Lett. 2003 Mar 13;538(1-3):77-80. 
Webre DJ, Wolanin PM, Stock JB.
Bacterial chemotaxis.
Curr Biol. 2003 Jan 21;13(2):R47-9. 
Da Re S, Tolstykh T, Wolanin PM, Stock JB.
Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism.
Protein Sci. 2002 Nov;11(11):2644-54. 
Levit MN, Stock JB.
Receptor methylation controls the magnitude of stimulus-response coupling in bacterial chemotaxis.
J Biol Chem. 2002 Sep27;277(39):36760-5. Epub 2002 Jul 15.
Francis NR, Levit MN, Shaikh TR, Melanson LA, Stock JB, DeRosier DJ.
Subunit organization in a soluble complex of tar, CheW, and CheA by electron microscopy.
J Biol Chem. 2002 Sep 27;277(39):36755-9. Epub 2002 Jul 15. 
Levit MN, Grebe TW, Stock JB.
Organization of the receptor-kinase signaling array that regulates Escherichia coli chemotaxis.
J Biol Chem. 2002 Sep 27;277(39):36748-54. Epub 2002 Jul 15. 
Wolanin PM, Thomason PA, Stock JB.
Histidine protein kinases: key signal transducers outside the animal kingdom.
Genome Biol. 2002 Sep 25;3(10):REVIEWS3013. Epub 2002 Sep 25. 
Thomason PA, Wolanin PM, Stock JB.
Signal transduction: receptor clusters as information processing arrays.
Curr Biol. 2002 Jun 4;12(11):R399-401. 
Stock JB, Levit MN, Wolanin PM.
Information processing in bacterial chemotaxis.
Sci STKE. 2002 May 14;2002(132):pe25. 
Vafai SB, Stock JB.
Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease.
FEBS Lett. 2002 May 8;518(1-3):1-4.
Levit MN, Abramczyk BM, Stock JB, Postel EH.
Interactions between Escherichia coli nucleoside-diphosphate kinase and DNA.
J Biol Chem. 2002 Feb 15;277(7):5163-7. Epub 2001 Dec 12. 
Mourey L, Da Re S, Pédelacq JD, Tolstykh T, Faurie C, Guillet V, Stock JB, Samama JP.
Crystal structure of the CheA histidine phosphotransfer domain that mediates response regulator phosphorylation in bacterial chemotaxis.
J Biol Chem. 2001 Aug 17;276(33):31074-82. Epub 2001 May 31. 
Tolstykh T, Lee J, Vafai S, Stock JB.
Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits.
EMBO J. 2000 Nov 1;19(21):5682-91. 
Wu J, Tolstykh T, Lee J, Boyd K, Stock JB, Broach JR.
Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo.
EMBO J. 2000 Nov 1;19(21):5672-81. Pubmed
Thomason PA, Traynor D, Stock JB, Kay RR.
The RdeA-RegA system, a eukaryotic phospho-relay controlling cAMP breakdown.
J Biol Chem. 1999 Sep 24;274(39):27379-84.
Da Re SS, Deville-Bonne D, Tolstykh T, V ron M, Stock JB.
Kinetics of CheY phosphorylation by small molecule phosphodonors.
FEBS Lett. 1999 Sep 3;457(3):323-6. 
Hakenbeck R, Grebe T, Zähner D, Stock JB.
beta-lactam resistance in Streptococcus pneumoniae: penicillin-binding proteins and non-penicillin-binding proteins.
Mol Microbiol. 1999 Aug;33(4):673-8. 
Levit MN, Liu Y, Stock JB.
Mechanism of CheA protein kinase activation in receptor signaling complexes.
Biochemistry. 1999 May 18;38(20):6651-8. 
Grebe TW, Stock JB.
The histidine protein kinase superfamily.
Adv Microb Physiol. 1999;41:139-227. 
Elowitz MB, Surette MG, Wolf PE, Stock JB, Leibler S.
Protein mobility in the cytoplasm of Escherichia coli.
J Bacteriol. 1999 Jan;181(1):197-203. 
Levit MN, Stock JB.
pH sensing in bacterial chemotaxis.
Novartis Found Symp. 1999;221:38-50; discussions 50-4. 
Levit MN, Liu Y, Stock JB.
Stimulus response coupling in bacterial chemotaxis: receptor dimers in signalling arrays.
Mol Microbiol. 1998 Nov;30(3):459-66. 
Alon U, Camarena L, Surette MG, Aguera y Arcas B, Liu Y, Leibler S, Stock JB.
Response regulator output in bacterial chemotaxis.
EMBO J. 1998 Aug 3;17(15):4238-48.
Liu Y, Levit M, Lurz R, Surette MG, Stock JB.
Receptor-mediated protein kinase activation and the mechanism of transmembrane signaling in bacterial chemotaxis.
EMBO J. 1997 Dec 15;16(24):7231-40. 
Surette MG, Stock JB.
Role of alpha-helical coiled-coil interactions in receptor dimerization, signaling, and adaptation during bacterial chemotaxis.
J Biol Chem. 1996 Jul 26;271(30):17966-73. 
Zähner D, Grebe T, Guenzi E, Krauss J, van der Linden M, Terhune K, Stock JB, Hakenbeck R.
Resistance determinants for beta-lactam antibiotics in laboratory mutants of Streptococcus pneumoniae that are involved in genetic competence.
Microb Drug Resist. 1996 Summer;2(2):187-91. 
de Jonge R, Teixeira de Mattos MJ, Stock JB, Neijssel OM.
Pyrroloquinoline quinone, a chemotactic attractant for Escherichia coli.
J Bacteriol. 1996 Feb;178(4):1224-6. 
Surette MG, Levit M, Liu Y, Lukat G, Ninfa EG, Ninfa A, Stock JB.
Dimerization is required for the activity of the protein histidine kinase CheA that mediates signal transduction in bacterial chemotaxis.
J Biol Chem. 1996 Jan 12;271(2):939-45. 
Hakenbeck R, Stock JB.
Analysis of two-component signal transduction systems involved in transcriptional regulation.
Methods Enzymol. 1996;273:281-300. 
Regazzi R, Sasaki T, Takahashi K, Jonas JC, Volker C, Stock JB, Takai Y, Wollheim CB.
Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells: comparison with the effect of Rab3AL peptide.
Biochim Biophys Acta. 1995 Sep 21;1268(3):269-78.
Philips MR, Staud R, Pillinger M, Feoktistov A, Volker C, Stock JB, Weissmann G.
Activation-dependent carboxyl methylation of neutrophil G-protein gamma subunit.
Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2283-7.
Volker C, Stock JB.
Carboxyl methylation of Ras-related proteins.
Methods Enzymol. 1995;255:65-82. 
Volker C, Pillinger MH, Philips MR, Stock JB.
Prenylcysteine analogs to study function of carboxylmethylation in signal transduction.
Methods Enzymol. 1995;250:216-25. 
McCleary WR, Stock JB.
Acetyl phosphate and the activation of two-component response regulators.
J Biol Chem. 1994 Dec 16;269(50):31567-72.
Pillinger MH, Volker C, Stock JB, Weissmann G, Philips MR.
Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophils.
J Biol Chem. 1994 Jan 14;269(2):1486-92.
Stock AM, Martinez-Hackert E, Rasmussen BF, West AH, Stock JB, Ringe D, Petsko GA.
Structure of the Mg(2+)-bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis.
Biochemistry. 1993 Dec 14;32(49):13375-80. 
Metz SA, Rabaglia ME, Stock JB, Kowluru A.
Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins.
Biochem J. 1993 Oct 1;295 ( Pt 1):31-40. 
McCleary WR, Stock JB, Ninfa AJ.
Is acetyl phosphate a global signal in Escherichia coli?
J Bacteriol. 1993 May;175(10):2793-8. 
Philips MR, Pillinger MH, Staud R, Volker C, Rosenfeld MG, Weissmann G, Stock JB.
Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils.
Science. 1993 Feb 12;259(5097):977-80.
Huzoor-Akbar, Wang W, Kornhauser R, Volker C, Stock JB.
Protein prenylcysteine analog inhibits agonist-receptor-mediated signal transduction in human platelets.
Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):868-72. 
Lukat GS, Stock JB.
Response regulation in bacterial chemotaxis.
J Cell Biochem. 1993 Jan;51(1):41-6. 
Lupas AN, Lupas JM, Stock JB.
Do G protein subunits associate via a three-stranded coiled coil?
FEBS Lett. 1992 Dec 14;314(2):105-8. 
Stock JB, Surette MG, McCleary WR, Stock AM.
Signal transduction in bacterial chemotaxis.
J Biol Chem. 1992 Oct 5;267(28):19753-6. 
Feng J, Atkinson MR, McCleary W, Stock JB, Wanner BL, Ninfa AJ.
Role of phosphorylated metabolic intermediates in the regulation of glutamine synthetase synthesis in Escherichia coli.
J Bacteriol. 1992 Oct;174(19):6061-70.
Camps M, Hou C, Sidiropoulos D, Stock JB, Jakobs KH, Gierschik P.
Stimulation of phospholipase C by guanine-nucleotide-binding protein beta gamma subunits.
Eur J Biochem. 1992 Jun 15;206(3):821-31. 
Lukat GS, McCleary WR, Stock AM, Stock JB.
Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors.
Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):718-22. 
Volker C, Miller RA, McCleary WR, Rao A, Poenie M, Backer JM, Stock JB.
Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction.
J Biol Chem. 1991 Nov 15;266(32):21515-22. 
Lukat GS, Lee BH, Mottonen JM, Stock AM, Stock JB.
Roles of the highly conserved aspartate and lysine residues in the response regulator of bacterial chemotaxis.
J Biol Chem. 1991 May 5;266(13):8348-54. 
Stock JB, Lukat GS, Stock AM.
Bacterial chemotaxis and the molecular logic of intracellular signal transduction networks.
Annu Rev Biophys Biophys Chem. 1991;20:109-36. 
Lukat GS, Stock AM, Stock JB.
Divalent metal ion binding to the CheY protein and its significance to phosphotransfer in bacterial chemotaxis.
Biochemistry. 1990 Jun 12;29(23):5436-42. 
Stock JB, Stock AM, Mottonen JM.
Signal transduction in bacteria.
Nature. 1990 Mar 29;344(6265):395-400. 
Stock JB, Ninfa AJ, Stock AM.
Protein phosphorylation and regulation of adaptive responses in bacteria.
Microbiol Rev. 1989 Dec;53(4):450-90. 
Igo MM, Ninfa AJ, Stock JB, Silhavy TJ.
Phosphorylation and dephosphorylation of a bacterial transcriptional activator by a transmembrane receptor.
Genes Dev. 1989 Nov;3(11):1725-34. 
Stock AM, Mottonen JM, Stock JB, Schutt CE.
Three-dimensional structure of CheY, the response regulator of bacterial chemotaxis.
Nature. 1989 Feb 23;337(6209):745-9.
Stock AM, Wylie DC, Mottonen JM, Lupas AN, Ninfa EG, Ninfa AJ, Schutt CE, Stock JB.
Phosphoproteins involved in bacterial signal transduction.
Cold Spring Harb Symp Quant Biol. 1988;53 Pt 1:49-57. 
Stock AM, Stock JB.
Purification and characterization of the CheZ protein of bacterial chemotaxis.
J Bacteriol. 1987 Jul;169(7):3301-11. 
Simms SA, Stock AM, Stock JB.
Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria.
J Biol Chem. 1987 Jun 25;262(18):8537-43. 
Snyder MA, Stock JB, Koshland DE Jr.
Carboxylmethyl esterase of bacterial chemotaxis.
Methods Enzymol. 1984;106:321-30.
Stock JB, Clarke S, Koshland DE Jr.
The protein carboxylmethyltransferase involved in Escherichia coli and Salmonella typhimurium chemotaxis.
Methods Enzymol. 1984;106:310-21. 
Stock JB, Waygood EB, Meadow ND, Postma PW, Roseman S.
Sugar transport by the bacterial phosphotransferase system. The glucose receptors of the Salmonella typhimurium phosphotransferase system.
J Biol Chem. 1982 Dec 10;257(23):14543-52.
Koshland DE Jr, Goldbeter A, Stock JB.
Amplification and adaptation in regulatory and sensory systems.
Science. 1982 Jul 16;217(4556):220-5. 
Stock JB, Koshland DE Jr.
Changing reactivity of receptor carboxyl groups during bacterial sensing.
J Biol Chem. 1981 Nov 10;256(21):10826-33. 
Stock JB, Maderis AM, Koshland DE Jr.
Bacterial chemotaxis in the absence of receptor carboxylmethylation.
Cell. 1981 Nov;27(1 Pt 2):37-44. 
Snyder MA, Stock JB, Koshland DE Jr.
Role of membrane potential and calcium in chemotactic sensing by bacteria.
J Mol Biol. 1981 Jun 25;149(2):241-57. 
Stock JB, Koshland DE Jr.
A cyclic mechanism for excitation and adaptation.
Curr Top Cell Regul. 1981;18:505-17. 
Postma PW, Stock JB.
Enzymes II of the phosphotransferase system do not catalyze sugar transport in the absence of phosphorylation.
J Bacteriol.1980 Feb;141(2):476-84. 
Stock JB, Koshland DE Jr.
A protein methylesterase involved in bacterial sensing.
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3659-63.
Stock JB, Rauch B, Roseman S.
Periplasmic space in Salmonella typhimurium and Escherichia coli.
J Biol Chem. 1977 Nov 10;252(21):7850-61.