Shenk Lab

Shenk Lab Publications

Recent Publications

Shron-Frilling R, Shenk T, (2014) Human cytomegalovirus pUL37x1-induced calcium flux activates PKCα, inducing altered cell shape and accumulation of cytoplasmic vesicles. Proc Natl Acad Sci USA 111:E1140-8 PubMed

Grady SL, Purdy JG, Rabinowitz JD, Shenk T. (2013) Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proc Natl Acad Sci. 110: E5006-15. Pubmed

Koyuncu E, Purdy JG, Rabinowitz JD, Shenk T. (2013) Saturated very long chain Fatty acids are required for the production of infectious human cytomegalovirus progeny. PLoS Pathog. 9: e1003333. Pubmed

O'Connor CM, Shenk T. (2012) Human cytomegalovirus pUL78 G protein-coupled receptor homologue is required for timely cell entry in epithelial cells but not fibroblasts. J Virol. 86: 11425-33. Pubmed

Archive

Gudleski-O'Regan N, Greco TM, Cristea IM, Shenk T. (2012) Increased expression of LDL receptor-related protein 1 during human cytomegalovirus infection reduces virion cholesterol and infectivity. Cell Host Microbe. 12: 86-96. Pubmed

Grady SL, Hwang J, Vastag L, Rabinowitz JD, Shenk T. (2012) Herpes simplex virus type 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase. J Virol. 86: 8259-8268. Pubmed

Terry LJ, Vastag L, Rabinowitz JD, Shenk T. (2012) Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc Natl Acad Sci. 109: 3071-3076. PubMed

Liu ST, Sharon-Friling R, Ivanova P, Milne SB, Myers DS, Rabinowitz JD, Brown HA, Shenk T. (2011) Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Proc Natl Acad Sci. 108: 12869-12874. PubMed

Vastag L, Koyuncu E, Grady SL, Shenk TE, Rabinowitz JD. (2011) Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog. 7: e1002124. PubMed

O'Connor CM, Shenk T. (2011) Human cytomegalovirus pUS27 G protein-coupled receptor homologue is required for efficient spread by the extracellular route but not for direct cell-to-cell spread. J Virol. 85: 3700-3707. PubMed

Womack A, Shenk T. (2010) Human cytomegalovirus tegument protein pUL71 is required for efficient virion egress. MBio. 1 pii: e00282-10. PubMed

Hargett D, Shenk TE. (2010) Experimental human cytomegalovirus latency in CD14+ monocytes. Proc Natl Acad Sci. 107: 20039-20044. PubMed

Moorman NJ, Sharon-Friling R, Shenk T, Cristea IM. (2010) A targeted spatial-temporal proteomics approach implicates multiple cellular trafficking pathways in human cytomegalovirus virion maturation. Mol Cell Proteomics. 9: 851-860. PubMed

Terhune SS, Moorman NJ, Cristea IM, Savaryn JP, Cuevas-Bennett C, Rout MP, Chait BT, Shenk T. (2010) Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. PLoS Pathog. 6: e1000965. PubMed

Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, Rout MP, Chait BT, Shenk T. (2010) Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol. 84: 7803-7814. PubMed

Moorman NJ, Shenk T. (2010) Rapamycin-resistant mTORC1 activity is required for herpesvirus replication. J Virol. 84: 5260-5269 .PubMed

Aoyagi M, Gaspar M, Shenk TE. (2010) Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1. Proc Natl Acad Sci. 107: 2640-2645. PubMed

Moorman NJ, Sharon-Friling R, Shenk T, Cristea IM. (2009) A targeted spatial-temporal proteomic approach implicates multiple cellular trafficking pathways in human cytomegalovirus virion maturation. Mol Cell Proteomics 9: 851-860. PubMed

Mitchell DP, Savaryn JP, Moorman NJ, Shenk T, Terhune SS. (2009) Human cytomegalovirus UL28 and UL29 open reading frames encode a spliced mRNA and stimulate accumulation of immediate-early RNAs. J Virol. 83: 10187-10197. PubMed

Lilja AE, Shenk T. (2008) Efficient replication of rhesus cytomegalovirus variants in multiple rhesus and human cell types. Proc Natl Acad Sci 105: 19950-19955. PubMed

Schröer J, Shenk T. (2008) Inhibition of cyclooxygenase activity blocks cell-to-cell spread of human cytomegalovirus. Proc Natl Acad Sci. 105: 19468-19473. PubMed

Munger J, Bennett BD, Parikh A, Feng XJ, McArdle J, Rabitz HA, Shenk T, Rabinowitz JD. (2008) Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol. 26: 1179-1186. PubMed

Cuevas-Bennett C, Shenk T. (2008) Dynamic histone H3 acetylation and methylation at human cytomegalovirus promoters during replication in fibroblasts. J Virol. 82: 9525-9536. PubMed

Murphy E, Shenk T. (2008) Human cytomegalovirus genome. Curr Top Microbiol Immunol. 325: 1-19. PubMed

Moorman NJ, Cristea IM, Terhune SS, Rout MP, Chait BT, Shenk T. (2008) Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. Cell Host Microbe. 3: 253-262. PubMed

Lilja AE, William Chang WL, Barry PA, Becerra SP, Shenk TE. (2007) Functional genetic analysis of Rhesus cytomegalovirus: Rh01 is an epithelial cell tropism factor. J Virol. 82: 2170-2181. PubMed

Wang D, Yu QC, Schröer J, Murphy E, Shenk T. (2007) Human cytomegalovirus uses two distinct pathways to enter retinal pigmented epithelial cells. Proc Natl Acad Sci USA 104: 20037-20042. PubMed

Terhune S, Torigoi E, Moorman N, Silva M, Qian Z, Shenk T, Yu D (2007). Human Cytomegalovirus UL38 protein blocks apoptosis. J Virol 81: 3109-3123. PubMed

Weinberger LS, Shenk T (2006). An HIV feedback resistor: auto-regulatory circuit deactivator and noise buffer. PLoS Biol 5: e9. PubMed

Sharon-Friling R, Goodhouse J, Colberg-Poley AM, Shenk T (2006). Human cytomegalovirus pUL37x1 induces the release of endoplasmic reticulum calcium stores. Proc Natl Acad Sci 103: 19117-19122. PubMed

Kulesza CA, Shenk T (2006). Murine cytomegalovirus encodes a stable intron that facilitates persistent replication in the mouse. Proc Natl Acad Sc.103: 18302-18307. PubMed

Feng X, Schroer J, Yu D, Shenk T (2006). Human Cytomegalovirus pUS24 is a virion protein that functions very early in the replication cycle. J Virol 80: 8371-8378. PubMed

Munger J, Yu D, Shenk T (2006). UL26-deficient human cytomegalovirus produces virions with hypophosphorylated pp28 tegument protein that is unstable within newly infected cells. J Virol 80: 3541-3548. PubMed

Gaspar M and Shenk T (2006). Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins. Proc Natl Acad Sci USA 103: 2821-2826 . PubMed

Wang D and Shenk T (2005). Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism. Proc Natl Acad Sci USA 102: 18153-18158. PubMed

Wang D and Shenk T (2005). Human cytomegalovirus UL131 open reading frame is required for epithelial cell tropism. J Virol 79: 10330-10338. PubMed

Silva MC, Schroer J and Shenk T (2005). Human cytomegalovirus cell-to-cell spread in the absence of an essential assembly protein. Proc Natl Acad Sci USA 102: 2081-2086. PubMed

Wang D, Bresnahan W and Shenk T (2004). Human cytomegalovirus encodes a highly specific RANTES decoy receptor. Proc Natl Acad Sci USA 101: 16642-16647. PubMed

Varnum SM, Streblow DN, Monroe ME, Smith P, Auberry KJ, Pasa-Tolic L, Wang D, Camp DG 2nd, Rodland K, Wiley S, Britt W, Shenk T, Smith RD, Nelson JA (2004). Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J Virol 78: 10960-10966. PubMed

Terhune SS, Schroer J and Shenk T (2004). RNAs are packaged into human cytomegalovirus virions in proportion to their intracellular concentration. J Virol 78: 10390-10398. PubMed

Nevels M, Paulus C and Shenk T (2004). Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation. Proc Natl Acad Sci USA 101: 17234-17239. PubMed

Nevels M, Brune W and Shenk T (2004). SUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replication. J Virol 78: 7803-7812. PubMed

Kulesza CA and Shenk T (2004). Human cytomegalovirus 5-kilobase immediate-early RNA is a stable intron. J Virol 78: 13182-13189. PubMed

Goodrum F, Jordan CT, Terhune SS, High K and Shenk T (2004). Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations. Blood 104: 687-695. PubMed

Challacombe JF, Rechtsteiner A, Gottardo R, Rocha LM, Browne EP, Shenk T, Altherr MR, Brettin TS (2004). Evaluation of the host transcriptional response to human cytomegalovirus infection. Physiol Genomics 18: 51-62. PubMed

Adamo JE, Schroer J and Shenk T (2004). Human cytomegalovirus TRS1 protein is required for efficient assembly of DNA-containing capsids. J Virol 78: 10221-10229. PubMed