Schwarzbauer Lab

Schwarzbauer Lab Publications

Recent Publications

Goyal R, Vega ME, Pastino AK, Singh S, Guvendiren M, Kohn J, Murthy NS, Schwarzbauer JE. Development of hybrid scaffolds with natural extracellular matrix deposited within synthetic polymeric fibers. J Biomed Mater Res A. 2017 Mar 28. [Epub ahead of print]

Miller CG, Budoff G, Prenner JL, Schwarzbauer JE. Minireview: Fibronectin in retinal disease. Exp Biol Med (Maywood). 2017 Jan;242(1):1-7. Epub 2016 Oct 20.

Harris GM, Madigan NN, Lancaster KZ, Enquist LW, Windebank AJ, Schwartz J, Schwarzbauer JE. Nerve Guidance by a Decellularized Fibroblast Extracellular Matrix. Matrix Biol. 2016 Sep 15. pii: S0945-053X(16)30196-2. [Epub ahead of print] Review.

Pastino AK, Greco TM, Mathias RA, Cristea IM, Schwarzbauer JE. Stimulatory effects of advanced glycation endproducts (AGEs) on fibronectin matrix assembly. Matrix Biol. 2017 May;59:39-53. Epub 2016 Jul 15.

Miller CG, Pozzi A, Zent R, Schwarzbauer JE. Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells. Mol Biol Cell. 2014 Aug 15;25(16):2342-50. Epub 2014 Jun 18.

Singh P, Schwarzbauer JE. Fibronectin matrix assembly is essential for cell condensation during chondrogenesis. J Cell Sci. 2014 Oct 15;127(Pt 20):4420-8. Epub 2014 Aug 21.

Miller CG, Pozzi A, Zent R, Schwarzbauer JE. Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells. Mol Biol Cell. 2014 Aug 15;25(16):2342-50. Epub 2014 Jun 18.

Wong MC, Kennedy WP, Schwarzbauer JE. Transcriptionally regulated cell adhesion network dictates distal tip cell directionality. Dev Dyn. 2014 Aug;243(8):999-1010. Epub 2014 May 26.

Park J, Schwarzbauer JE. Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition. Oncogene. 2014 Mar 27;33(13):1649-57. Epub 2013 Apr 29.

Singh S, Bandini SB, Donnelly PE, Schwartz J, Schwarzbauer JE. A cell-assembled, spatially aligned extracellular matrix to promote directed tissue development. J Mater Chem B Mater Biol Med. 2014 Mar 21;2(11):1449-1453.

Meighan CM, Schwarzbauer JE. α Integrin cytoplasmic tails have tissue-specific roles during C. elegans development. Int J Dev Biol. 2014;58(5):325-33.

Desai VD, Hsia HC, Schwarzbauer JE. Reversible modulation of myofibroblast differentiation in adipose-derived mesenchymal stem cells. PLoS One. 2014 Jan 23;9(1):e86865.

Taylor-Weiner H, Schwarzbauer JE, Engler AJ. Defined Extracellular Matrix Components are Necessary for Definitive Endoderm Induction. Stem Cells. 2013 Oct;31(10):2084-94.

Donnelly PE, Jones CM, Bandini SB, Singh S, Schwartz J, Schwarzbauer JE. A Simple Nanoscale Interface Directs Alignment of a Confluent Cell Layer on Oxide and Polymer Surfaces. J Mater Chem B Mater Biol Med. 2013 Aug 7;1(29):3553-3561.

Carraher CL, Schwarzbauer JE. Regulation of matrix assembly through rigidity-dependent fibronectin conformational changes. J Biol Chem. 2013 May 24;288(21):14805-14. Epub 2013 Apr 15.


Hunt GC, Singh P, Schwarzbauer JE. Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells. Exp Cell Res. 2012 Sep 10;318(15):1820-31. Epub 2012 Jun 16.

Martynovsky M, Wong MC, Byrd DT, Kimble J, Schwarzbauer JE. mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites. Dev Biol. 2012 Aug 15;368(2):404-14. Epub 2012 Jun 23.

Singh P, Schwarzbauer JE. Fibronectin and stem cell differentiation - lessons from chondrogenesis. J Cell Sci. 2012 Aug 15;125(Pt 16):3703-12. Epub 2012 Sep 12. Review.

Wong MC, Schwarzbauer JE. Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite. Wiley Interdiscip Rev Dev Biol. 2012 Jul-Aug;1(4):519-31.

Chiang C, Karuri SW, Kshatriya PP, Schwartz J, Schwarzbauer JE, Karuri NW. (2012) Surface derivatization strategy for combinatorial analysis of cell response to mixtures of protein domains. Langmuir. 2012 Jan 10;28(1):548-56.

Schwarzbauer JE, DeSimone DW. Fibronectins, their fibrillogenesis, and in vivo functions. Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7).pii: a005041.

Salmerón-Sánchez M, Rico P, Moratal D, Lee TT, Schwarzbauer JE , García AJ. Role of material-driven fibronectin fibrillogenesis in cell differentiation. Biomaterials. 2011 Mar;32(8):2099-105. Epub 2010 Dec 24.

Sharma RI, Schwarzbauer JE, Moghe PV. Nanomaterials can dynamically steer cell responses to biological ligands. Small. 2011 Jan 17;7(2):242-51. Epub 2010 Dec 13.

Wong MC, Martynovsky M, Schwarzbauer JE. Analysis of cell migration using Caenorhabditis elegans as a model system. Methods Mol Biol. 2011;769:233-47.

Singh P, Carraher C, JE Schwarzbauer. Assembly of fibronectin extracellular matrix. Annu Rev Cell Dev Biol. 2010 Nov 10;26:397-419. Review.

Quinn JA, Graeber CT, Frackelton AR Jr, Kim M, Schwarzbauer JE, Filardo EJ. Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30. Mol Endocrinol. 2009 Jul;23(7):1052-64. Epub 2009 Apr 2.

Engler AJ, Chan M, Boettiger D, Schwarzbauer JE. A novel mode of cell detachment from fibrillar fibronectin matrix under shear. J Cell Sci. 2009 May 15;122(Pt 10):1647-53. Epub 2009 Apr 28.

Hunt GC, Schwarzbauer JE. Tightening the connections between cadherins and fibronectin matrix. Dev Cell. 2009 Mar;16(3):327-8.

Karuri NW, Lin Z, Rye HS, Schwarzbauer JE. Probing the conformation of the fibronectin III1-2 domain by fluorescence resonance energy transfer. J Biol Chem. 2009 Feb 6;284(6):3445-52. Epub 2008 Dec 8.

Williams SA, Schwarzbauer JE. A shared mechanism of adhesion modulation for tenascin-C and fibulin-1. Mol Biol Cell. 2009 Feb;20(4):1141-9. Epub 2008 Dec 24.

Ginsberg MH, Schwarzbauer JE. Cell-to-cell contact and extracellular matrix. Curr Opin Cell Biol. 2008 Oct;20(5):492-4. Epub 2008 Aug 3.

Meighan CM, Schwarzbauer JE. Temporal and spatial regulation of integrins during development. Curr Opin Cell Biol. 2008 Oct;20(5):520-4. Epub 2008 Jul 4. Review.

Williams CM, Engler AJ, Slone RD, Galante LL, Schwarzbauer JE. Fibronectin expression modulatesmammary epithelial cell proliferation during acinar differentiation. Cancer Res. 2008 May 1;68(9):3185-92.

Cram EJ, Fontanez KM, Schwarzbauer JE. Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase. Dev Dyn. 2008 Mar;237(3):837-46.

Galante LL, Schwarzbauer JE. Requirements for sulfate transport and the diastrophic dysplasia sulfate transporter in fibronectin matrix assembly. J Cell Biol. 2007 Dec 3;179(5):999-1009.

Engler AJ, Sweeney HL, Discher DE, Schwarzbauer JE. Extracellular matrix elasticity directs stem cell differentiation. J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):335.

Meighan CM, Schwarzbauer JE. Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors. Genes Dev. 2007 Jul 1;21(13):1615-20.

Wierzbicka-Patynowski I, Mao Y, Schwarzbauer JE. Continuous requirement for pp60-Src and phospho-paxillin during fibronectin matrix assembly by transformed cells. J Cell Physiol. 2007 Mar;210(3):750-6.

Pereira M, Sharma RI, Penkala R, Gentzel TA, Schwarzbauer JE, Moghe PV. Engineered cell-adhesive nanoparticles nucleate extracellular matrix assembly. Tissue Eng. 2007 Mar;13(3):567-78.

Dennes TJ, Hunt GC, Schwarzbauer JE, Schwartz J. High-yield activation of scaffold polymer surfaces to attach cell adhesion molecules. J Am Chem Soc. 2007 Jan 10;129(1):93-7.

Cram EJ, Shang H, Schwarzbauer JE. A systematic RNA interference screen reveals a cell migration gene network in C. elegans. J Cell Sci. 2006 Dec 1;119(Pt 23):4811-8. Epub 2006 Nov 7.

Hsia HC, Schwarzbauer JE. Adenoviral-mediated expression and local deposition of recombinant tenascin-C perturbs cell-dependent matrix contraction. J Surg Res. 2006 Nov;136(1):92-7. Epub 2006 Aug 22..

Mao Y, Schwarzbauer JE. Accessibility to the fibronectin synergy site in a 3D matrix regulates engagement of a5b1 and avb3 integrin receptors. Cell Commun Adhes. 2006 Sep-Dec;13(5-6):267-77.

Midwood KS, Mao Y, Hsia HC, Valenick LV, Schwarzbauer JE. Modulation of cell-fibronectin matrix interactions during tissue repair. J Investig Dermatol Symp Proc. 2006 Sep;11(1):73-8. Review.

Sharma RI, Pereira M, Schwarzbauer JE, Moghe PV. Albumin derived nanocarriers: Substrates for enhanced cell adhesive ligand display and cell motility. Biomaterials. 2006 Jul;27(19):3589-98. Epub 2006 Mar 9.

Valenick LV, Schwarzbauer JE. Ligand density and integrin repertoire regulate cellular response to LPA. Matrix Biol. 2006 May;25(4):223-31. Epub 2006 Feb 28.

Mao Y, Schwarzbauer JE. Stimulatory effects of a three-dimensional microenvironment on cell-mediated fibronectin fibrillogenesis. J Cell Sci. 2005 Oct 1;118(Pt 19):4427-36. Epub 2005 Sep 13.

Valenick LV, Hsia HC, Schwarzbauer JE. Fibronectin fragmentation promotes a4b1 integrin-mediated contraction of a fibrin-fibronectin provisional matrix. Exp Cell Res. 2005 Sep 10;309(1):48-55.

Mao Y, Schwarzbauer JE. Fibronectin fibrillogenesis, a cell-mediated matrix assembly process. Matrix Biol. 2005 Sep;24(6):389-99. Review.

Hsia HC, Schwarzbauer JE. Meet the tenascins: multifunctional and mysterious. J Biol Chem. 2005 Jul 22;280(29):26641-4. Epub 2005 Jun 2. Review.

Lee M, Shen B, Schwarzbauer JE, Ahn J, Kwon J. Connections between integrins and Rac GTPase pathways control gonad formation and function in C. elegans. Biochim Biophys Acta. 2005 May 25;1723(1-3):248-55. Epub 2005 Jan 22.

Wierzbicka-Patynowski I, Mao Y, Schwarzbauer JE. Analysis of fibronectin matrix assembly. Curr Protoc Cell Biol. 2004 Dec;Chapter 10:Unit 10.12.

Midwood KS, Valenick LV, Hsia HC, Schwarzbauer JE. Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4. Mol Biol Cell. 2004 Dec;15(12):5670-7. Epub 2004 Oct 13.

Meighan CM, Cram EJ, Schwarzbauer JE. Organogenesis: cutting to the chase. Curr Biol. 2004 Nov 23;14(22):R948-50. Review.

Midwood KS, Carolus MD, Danahy MP, Schwarzbauer JE, Schwartz J. Easy and efficient bonding of biomolecules to an oxide surface of silicon. Langmuir. 2004 Jun 22;20(13):5501-5.

Danahy MP, Avaltroni MJ, Midwood KS, Schwarzbauer JE, Schwartz J. Self-assembled monolayers of a, w-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization. LLangmuir. 2004 Jun 22;20(13):5333-7.

Midwood KS, Williams LV, Schwarzbauer JE. Tissue repair and the dynamics of the extracellular matrix. Int J Biochem Cell Biol. 2004 Jun;36(6):1031-7. Review.

Cram EJ, Schwarzbauer JE. The talin wags the dog: New insights into integrin activation. Trends Cell Biol. 2004 Feb;14(2):55-7. Review.

Cram EJ, Clark SG, Schwarzbauer JE. Talin loss of function uncovers roles in cell migration and contractility in C. elegans. J Cell Sci. 2003 Oct 1;116(Pt 19):3871-8. Epub 2003 Aug 12.

Clark RA, An JQ, Greiling D, Khan A, Schwarzbauer JE. Fibroblast migration on fibronectin requires three distinct functional domains. J Invest Dermatol. 2003 Oct;121(4):695-705.

Wierzbicka-Patynowski I, Schwarzbauer JE. The ins and outs of fibronectin matrix assembly. J Cell Sci. 2003 Aug 15;116(Pt 16):3269-76. Review.

Gawalt, E. S., M. J. Avaltroni, M. P. Danahy, B. M. Silverman, E. L. Hanson, K. S. Midwood, J. E. Schwarzbauer, and J. Schwartz. Bonding organics to Ti alloys: Facilitating human osteoblast attachment and spreading on surgical implant materials.Langmuir 2003, 19, 200-204.

Gleason, N. J., C. J. Nodes, E. M. Higham, N. Guckert, I. A. Aksay, J. E. Schwarzbauer, and J. D. Carbeck. Patterning proteins and cells using two-dimensional arrays of colloids.Langmuir 2003, 19, 513-518.

Midwood KS, Schwarzbauer JE. Tenascin-C modulates matrix contraction via focal adhesion kinase- and Rho-mediated signaling pathways. Mol Biol Cell. 2002 Oct;13(10):3601-13.

García AJ, Schwarzbauer JE, Boettiger D. Distinct activation states of alpha5beta1 integrin show differential binding to RGD and synergy domains of fibronectin. Biochemistry. 2002 Jul 23;41(29):9063-9.

Wierzbicka-Patynowski I, Schwarzbauer JE. Regulatory role for Src and PI3-kinase in initiation of fibronectin matrix assembly. J Biol Chem. 2002 May 31;277(22):19703-8. Epub 2002 Mar 23.

Midwood KS, Schwarzbauer JE. Elastic fibers: building bridges between cells and their matrix. Curr Biol. 2002 Apr 16;12(8):R279-81.

Midwood KS, Wierzbicka-Patynowski I, Schwarzbauer JE. Preparation and analysis of synthetic multicomponent extracellular matrix. Methods Cell Biol. 2002;69:145-61.

Lee M, Cram EJ, Shen B, Schwarzbauer JE. Roles for bpat-3 integrins in development and function of Caenorhabditis elegans muscles and gonads. J Biol Chem. 2001 Sep 28;276(39):36404-10. Epub 2001 Jul 25.

Sechler JL, Rao H, Cumiskey AM, Vega-Colón I, Smith MS, Murata T, Schwarzbauer JE. A novel fibronectin binding site required for fibronectin fibril growth during matrix assembly. J Cell Biol. 2001 Sep 3;154(5):1081-8.

Wenk MB, Midwood KS, Schwarzbauer JE. Tenascin-C suppresses Rho activation. J Cell Biol. 2000 Aug 21;150(4):913-20.

Brenner KA, Corbett SA, Schwarzbauer JE. Regulation of fibronectin matrix assembly by activated Ras in transformed cells. Oncogene. 2000 Jun 29;19(28):3156-63.

Sechler JL, Cumiskey AM, Gazzola DM, Schwarzbauer JE. A novel RGD-independent fibronectin assembly pathway initiated by a4b1 integrin binding to the alternatively spliced V region. J Cell Sci. 2000 Apr;113 (Pt 8):1491-8.

Darribère T, Schwarzbauer JE. Fibronectin matrix composition and organization can regulate cell migration during amphibian development. Mech Dev. 2000 Apr;92(2):239-50.