Schupbach Lab

Schüpbach Lab Publications

2013-

Li W, Klovstad M, Schüpbach T. (2014) Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A. Development. 141: 3910-21. Pubmed

Devergne O, Tsung K, Barcelo G, Schüpbach T. (2014) Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci. 111: 7689-94. Pubmed

McKoy AF, Chen J, Schupbach T, Hecht MH. (2014) Structure activity relationships for a series of compounds that inhibit aggregation of the Alzheimer's peptide, Aβ42. Chem Biol Drug Des. 84: 505-12. Pubmed

Domanitskaya E, Anllo L, Schüpbach T. (2014) Phantom, a cytochrome P450 enzyme essential for ecdysone biosynthesis, plays a critical role in the control of border cell migration in Drosophila. Dev Biol. 386: 408-18. Pubmed

Fontenele M, Lim B, Oliveira D, Buffolo M, Perlman DH, Schupbach T, Araujo H. (2013) Calpain A modulates Toll responses by limited Cactus/IκB proteolysis. Mol Biol Cell. 24: 2966-80. Pubmed

Osterfield M, Du X, Schüpbach T, Wieschaus E, Shvartsman SY. (2013) Three-dimensional epithelial morphogenesis in the developing Drosophila egg. Dev Cell. 24: 400-410. Pubmed

1993-2012

McKoy AF, Chen J, Schupbach T, Hecht MH. (2012) A novel inhibitor of Aβ peptide aggregation: from high throughput screening to efficacy in an animal model for Alzheimer's disease. J Biol Chem. 287: 38992-39000.Pubmed

Ferguson SB, Blundon MA, Klovstad MS, Schüpbach T. (2012) Modulation of gurken translation by insulin and TOR signaling in Drosophila. J Cell Sci. 125: 1407-1419. Pubmed

Domanitskaya E, Schüpbach T. (2012) CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster. J Cell Sci. 125: 399-410. PubMed

Pane A, Jiang P, Zhao DY, Singh M, Schüpbach T. (2011) The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline. EMBO J. 30: 4601-4615. Pubmed

Cheung LS, Schüpbach T, Shvartsman SY. (2011) Pattern formation by receptor tyrosine kinases: analysis of the Gurken gradient in Drosophila oogenesis. Curr Opin Genet Dev. 21: 719-725. PubMed

Sun Y, Yan Y, Denef N, Schüpbach T. (2011) Regulation of somatic myosin activity by Protein Phosphatase 1{beta} controls Drosophila oocyte polarization. Development. 138: 1991-2001 PubMed

Yan Y, Denef N, Tang C, Schüpbach T. (2011) Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling. Development. 138: 1697-1703. PubMed

Sethi N, Yan Y, Quek D, Schupbach T, Kang Y. (2010) Rabconnectin-3 is a functional regulator of mammalian notch signaling. J Biol Chem. 285: 34757-34764. PubMed

Yan Y, Denef N, Schüpbach T. (2009) The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila. Dev Cell. 17: 387-402. PubMed

Schüpbach T. (2009) Developmental biology: Pipe's smoking guns. Curr Biol. 19: R548-550. PubMed

Yakoby, N., Bristow, C.A., Gong, D., Schafer, X., Lembong, J., Zartman, J.J., Halfon, M.S., Schupbach, T., Shvartsman, S. (2008) A combinatorial code for pattern formation in Drosophila oogenesis. Dev Cell 15: 725-737.PubMed

Jaramillo AM, Weil TT, Goodhouse J, Gavis ER, Schupbach T. (2008) The dynamics of fluorescently labeled endogenous gurken mRNA in Drosophila. J Cell Sci.121: 887-894. PubMed

Klovstad M, Abdu U, Schüpbach T. (2008) Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint. PLoS Genet.4: e31. PubMed

Denef N, Chen Y, Weeks SD, Barcelo G, Schüpbach T. (2008) Crag regulates epithelial architecture and polarized deposition of basement membrane proteins in Drosophila. Dev Cell. 14: 354-364. PubMed

Yakoby N, Lembong J, Schüpbach T, Shvartsman SY. (2008) Drosophila eggshell is patterned by sequential action of feedforward and feedback loops. Development 135: 343-351. PubMed

Clouse KN, Ferguson SB, Schüpbach T. (2008) Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila. Dev Biol 313: 713-724. PubMed

Pane A, Wehr K, Schüpbach T (2007). zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev Cell 12: 851-862. PubMed

Swan A and Schupbach T (2007). The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. Development 134: 891-899. PubMed

Chen Y, Pane A, Schupbach T (2007). Cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila. Curr Biol 17: 637-642. PubMed

Goentoro LA, Reeves GT, Kowal CP, Martinelli L, Schupbach T, Shvartsman SY (2006). Quantifying the Gurken morphogen gradient in Drosophila oogenesis. Dev Cell 11: 263-272. PubMed

Chen Y, Schupbach T (2006). The role of brinker in eggshell patterning. Mech Dev 123: 395-406. PubMed

Wehr K, Swan A, Schupbach T (2006). Deadlock, a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo. Dev Biol 294: 406-417. PubMed

Abdu U, Bar D and Schupbach T (2006). spn-F encodes a novel protein that is involved in the organization of specialized microtubule networks in Drosophila. Development 133: 1477-1484. PubMed

Swan A, Barcelo G, Schupbach T (2005). Drosophila Cks30A interacts with Cdk1 to target Cyclin A for destruction in the female germline. Development 132: 3669-3678. PubMed

Swan A and Schupbach T (2005). Drosophila female meiosis and embryonic syncytial mitosis use specialized Cks and CDC20 proteins for cyclin destruction. Cell Cycle 4: 1332-1334. PubMed

Murthy M, Ranjan R, Denef N, Higashi ME, Schupbach T, Schwarz TL (2005). Sec6 mutations and the Drosophila exocyst complex. J Cell Sci 118: 1139-5110. PubMed

Goodrich JS, Clouse KN and Schupbach T (2004). Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis. Development 131: 1949-1958.PubMed

Ohlmeyer JT and Schupbach T (2003). Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during Drosophila oogenesis. Development 130: 6339-6349. PubMed

Gupta T and Schupbach T (2003). Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis. Development 130: 6075-6087. PubMed

Van Buskirk C and Schupbach T (2002). Half pint regulates alternative splice site selection in Drosophila. Dev Cell 2: 343-353. PubMed

Abdu U, Brodsky M and Schupbach T (2002). Activation of a meiotic checkpoint during Drosophila oogenesis regulates the translation of Gurken through Chk2/Mnk. Curr Biol 12: 1645-1651. PubMed

Pai LM, Barcelo G and Schupbach T (2000). D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis. Cell 103: 51-61. PubMed

Norvell A, Kelley RL, Wehr K and Schupbach T (1999). Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis. Genes Dev 13: 864-876. PubMed

Nilson LA and Schupbach T (1998). Localized requirements for windbeutel and pipe reveal a dorsoventral prepattern within the follicular epithelium of the Drosophila ovary. Cell 93: 253-262. PubMed

Neuman-Silberberg FS and Schupbach T (1993). The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein. Cell 75: 165-174. PubMed