Gitai Lab Publications

Recent Publications

Castellana M, Wilson MZ, Yu Y, Joshi P, Cristea IM, Rabinowitz JD, Gitai Z, Wingreen NS. (2014) Enzyme clustering accelerates processing of intermediates through metabolic channeling.  Nat. Biotechnol. 32(10):1011-8. doi: 10.1038.nbt.3018 PubMed

Barry RM, Bitbol AF, Lorestani A., Charles EJ, Habrian CH, Hansen JM, Li HJ, Baldwin EP, Wingreen NS, Kollman JM, Gitai Z.  (2014) Large-scale filament formation inhibits the activity of CTP synthetase.  Elife Jul 16;3:e03638. doi: 10.7554/eLife.03638 PubMed

Billings G, Ouzounov N, Ursell T, Desmarais SM, Shaevitz J, Gitai, Huang KC. (2014) De novo morphogenesis in L-forms via geometric control of cell growth.  Mol. Microbiol. 93(5):883-96. doi: 10.1111/mmi.12703. PubMed

Persat A, Gitai Z. (2014) Bacterial evolution: rewiring modules to get in shape.  Curr. Biol. 24(11):R522-4. doi: 10.1016/j.cub.2014.04.022. PubMed

Persat A, Stone HA, Gitai Z. (2014) The curved shape of Caulobacter cresentus enhances surface colonization in flow.  Nat. Commun. 5:3824. doi: 10.1038/ncomms4824. PubMed

Ursell TS, Nguyen J, Monds RD, Colavin A, Billings G, Ouzounov N, Gitai Z, Shaevitz JW, Hunag KC. (2014) Rod-like bacterial shape is maintained by feedback between cell curvature and cytoskeletal localization. Proc. Natl. Acad. Sci. USA 111(11):E1025-34.  doi: 10.1073/pnas.1317174111.  PubMed

Lee TK, Tropini C, Hsin J, Desmarais SM, Ursell TS, Gong E, Gitai Z, Monds RD, Huang KC.  (2014)  A dynamically assembled cell wall synthesis machinery buffers cell growth.  Proc. Natl. Acad. Sci. USA 111(12):554-9.  doi: 10.1073/pnas.1313826111. PubMed


Cowles KN, Moser TS, Siryaporn A, Nyakudarika N, Dixon W, Turner JJ, Gitai Z. (2013) The putative Poc complex controls two distinct Pseudomonas aeruginosa polar motility mechanisms. Mol Microbiol. 90: 923-38. PubMed

Yakhnina AA, Gitai Z. (2013) Diverse functions for six glycosyltransferases in Caulobacter crescentus cell wall assembly. J Bacteriol. 195: 4527-35. PubMed

Klein EA, Schlimpert S, Hughes V, Brun YV, Thanbichler M, Gitai Z. (2013) Physiological role of stalk lengthening in Caulobacter crescentus. Commun Integr Biol. 6: e24561. PubMed

Wilson MZ, Gitai Z. (2013) Beyond the cytoskeleton: mesoscale assemblies and their function in spatial organization. Curr Opin Microbiol. 16: 177-83. PubMed

Klein EA, Gitai Z. (2013) Draft genome sequence of uropathogenic Escherichia coli strain J96. Genome Announc. 1. pii: e00245-12. PubMed

Bos J, Yakhnina AA, Gitai Z. (2012) BapE DNA endonuclease induces an apoptotic-like response to DNA damage in Caulobacter. Proc Natl Acad Sci. 109: 18096-18101. PubMed

Yakhnina AA, Gitai Z. (2012) The small protein MbiA interacts with MreB and modulates cell shape in Caulobacter crescentus. Mol Microbiol. 85: 1090-1104. PubMed

van Teeffelen S, Shaevitz JW, Gitai Z. (2012) Image analysis in fluorescence microscopy: bacterial dynamics as a case study. Bioessays. 34: 427-436. PubMed

Ingerson-Mahar M, Gitai Z. (2012) A growing family: the expanding universe of the bacterial cytoskeleton. FEMS Microbiol Rev. 36: 256-266. PubMed

Barry RM, Gitai Z. (2011) Self-assembling enzymes and the origins of the cytoskeleton. Curr Opin Microbiol. 14: 704-711. PubMed

Shaevitz J.W. and Gitai Z. (2010). The structure and Function of Bacterial Actin Homologs. CSH Pers. Biol.[PDF]

McKenney P.T., Driks A., Eskandarian H.A., Grabowski P., Guberman J., Wang K.H., Gitai Z., and Eichenberger P. (2010). A Distance-Weighted Interaction Map Reveals a Previously Uncharacterized Layer of the Bacillus subtilis Spore Coat. Curr. Biol. 20:934-938. [PDF]

Cowles K.N. & Gitai Z (2010) Surface association and the MreB cytoskeleton regulate pilus production, localization and function in Pseudomonas aeruginosammi. Mol. Microbio. 76:1411-1426. [PDF]

Werner JN, Chen EY, Guberman JM, Zippilli AR, Irgon JJ and Gitai Z (2009). Quantitative genome-scale analysis of protein localization in an asymmetric bacterium. PNAS 106: 7858-7863.  [PDF]  [Localisome resources]

Gitai, Z. (2009). New fluorescence microscopy methods for microbiology: sharper, faster, and quantitative. Curr. Opin. Micro. 12:341-346. [PDF]

Shebelut, C.W., Jensen R.B., Gitai Z. (2009). Growth conditions regulate the regulate the requirements for Caulobacter chromosome segregation. J. Bacteriol. 191(3):1097-100. [PDF]

Huang K.C., Mukhopadhyay R., Wen B., Gitai Z., Wingreen N.S. (2008). Cell shape and cell-wall organization in Gram-negative bacteria. PNAS 105(49):19282-7. [PDF]

Guberman J.M., Fay A., Dworkin J., Wingreen N.S. and Gitai Z. (2008). PSICIC: noise and asymmetry in bacterial division revealed by computational image analysis at sub-pixel resolution. PLoS Comput Biol 11: e1000233.  [PDF][PSICIC resources]

Silhavy T.J., Gitai Z. (2008). Sex to the rescue. Nat Methods 5(9):759-60. [PDF]

Briegel A., Ding H.J., Li Z., Werner J., Gitai Z., Dias D.P., Jensen R.B., Jensen G.J. (2008) Location and architecture of the Caulobacter cresentus chemoreceptor array. Mo.l Microbiol. 69(1):30-41. [PDF]

Gitai Z (2007). Diversification and specialization of the bacterial cytoskeleton. Curr. Opin. Cell Biol. 19(1):5-12. [PDF]

Kim S.Y., Gitai Z., Kinkhabwala A., Shapiro L., Moerner W.E. (2006). Single molecules of the bacterial actin MreB undergo directed treadmilling motion in Caulobacter crescentus. PNAS 103(29):10929-34. [PDF]

Gitai Z (2006). Plasmid segregation: a new class of cytoskeletal proteins emerges. Curr Biol 16: R133-136.  [PDF]

Gitai Z, Thanbichler M and Shapiro L (2005). The choreographed dynamics of bacterial chromosomes. Trends Microbiol 13: 221-228.  [PDF]

Gitai Z, Dye NA, Reisenauer A, Wachi M and Shapiro L (2005). MreB actin-mediated segregation of a specific region of a bacterial chromosome. Cell 120: 329-341.  [PDF]

Gitai Z (2005). The new bacterial cell biology: moving parts and subcellular architecture. Cell 120: 577-586.  [PDF]

Dye NA, Pincus Z, Theriot JA, Shapiro L and Gitai Z (2005). Two independent spiral structures control cell shape in Caulobacter. Proc Natl Acad Sci USA 102: 18608-18613.  [PDF]

Gitai Z, Dye N and Shapiro L (2004). An actin-like gene can determine cell polarity in bacteria. Proc Natl Acad Sci USA 101: 8643-8648.  [PDF]

Gitai Z and Shapiro L (2003). Bacterial cell division spirals into control. Proc Natl Acad Sci USA 100: 7423-7424.  [PDF]