Lynn W. Enquist
Henry L. Hillman Professor
Professor Princeton Neuroscience Institute
Lynn W. Enquist is Henry L. Hillman Professor in Molecular Biology and Professor in the Princeton Neuroscience Institute at Princeton University.
He received his BS degree in Bacteriology at South Dakota State University in 1967. He received his Ph.D. in Microbiology from Medical College of Virginia, Virginia Commonwealth University in 1971 with S. Gaylen Bradley studying streptomyces biology. He did postdoctoral training at the Roche Institute of Molecular Biology from 1971 to 1973 studying bacteriophage lambda replication and recombination with Ann Skalka. He served in the US Public Health Service from 1973-1981. He was a senior staff fellow at the National Institutes of Health in the laboratory of Dr. Philip Leder working with Robert Weisberg from 1974-1977 studying bacteriophage lambda site-specific recombination and development of recombinant DNA technology. He held a tenured staff position in the National Cancer Institute from 1977 to 1981 where he continued the development of recombinant DNA technology and also began his work on neurotropic herpes viruses. George VandeWoude was his lab chief. In 1981 he left the National Cancer Institute to be Executive Scientist at Molecular Genetics Incorporated in Minnetonka, Minnesota where he worked on recombinant DNA based viral vaccines. In 1984, he joined DuPont as a Research Leader where he ran a laboratory studying neurotropic viruses. In 1990, he joined DuPont Merck Pharmaceutical Company where he was a Senior Research Fellow working on developing neurotropic viruses as tools for gene therapy and studying the mammalian nervous system. In 1993, he accepted the position of tenured full professor of Molecular Biology at Princeton University. He was chair of the department of Molecular Biology from 2004 to 2013.
His research interests are in the field of neurovirology, specifically on the mechanisms of herpesvirus spread and pathogenesis in the mammalian nervous system. His laboratory focuses on understanding the molecular mechanisms by which neuroinvasive alpha-herpesviruses invade and spread in the mammalian nervous system and how the nervous system responds to infection. His laboratory develops and uses imaging technology to define the molecular mechanisms of neuronal spread and subsequent pathogenesis. His work has also lead to the development of these viruses as tools to trace neuronal circuitry in living animals. He has published over 280 peer-reviewed papers, reviews, books and has 4 patents.
He is a Fellow of the American Academy of Microbiology and the American Association for the Advancement of Sciences (AAAS). He was member of the board of directors of the AAAS. He was a member of the National Science Advisory Board for Biosecurity. He was a member of the Scientific Council of the Pasteur Institute from 2007-2013. He was elected to the American Academy of Arts and Sciences. He was past President of the American Society for Virology and editor in chief for the Journal of Virology. He currently is the president of the American Society for Microbiology and the founding editor of the Annual Reviews of Virology.