Burdine Lab Members

Photo of Burdine Lab group

Photo of Burdine Lab group

Principal Investigator

Becky
Rebecca D. Burdine
Principal Investigator
 
Research Interest:  Left-right patterning in the vertebrate embryo
Rebecca Burdine Biography »

 Rebecca Burdine CVpdf-icon-25x25

Postdoctoral Fellows

Daniel Grimes
Daniel T. Grimes
Postdoctoral Fellow
Email Dan

Research Interest: I am investigating the roles of multiple extracellular signaling factors that are involved in zebrafish cardiac jogging; an early event during heart formation which positions atrial cells to the left and anterior of ventricular cells. I am particularly interested in how these signals cross-talk and are integrated by cells of the heart to control behaviors such as cell migration.

 Victoria Patterson 1
Victoria L. Patterson
Postdoctoral Fellow
Email Vicki

Research Interest: My research involves using experimental models to understand the etiology of human disease, with a particular interest in signaling during developmental biology. My current research focuses on the signaling pathways that direct heart development in vertebrates. I am especially interested in understanding how closely regulated processes such as gene expression, morphological changes and cell migration lead to a properly patterned heart and how mutations in key proteins result in disease states. Using zebrafish as a model, I am investigating how these types of mutations cause congenital heart defects in humans.

Graduate Students

Bright Arthur
Bright Arthur

Research Interest: Bright is rotating in the lab this summer and working with Dan Grimes on modeling genes that cause congenital heart defects in zebrafish.

Meagan 
Meagan Grant

Research Interest:  I am investigating the role of the FGF signaling in asymmetric cardiac morphogenesis. Specifically, I am interested in the role of this pathway in cardiac jogging, a phenomenon in which atrial cells are re-positioned to the anterior and left of ventricular cells. This leftward shift of the cardiac cone occurs simultaneously with its conversion into a linear tube. I aim to identify the FGF ligands, receptors, and transcriptional targets required for the proper re-positioning of the cardiac progenitors during late somitogenesis, and to determine how these factors function at the molecular level to regulate asymmetric cardiac development.

granton-thumb
Granton Jindal
Email Granton

Research Interest: My research focuses on using image analysis and quantitative modeling to analyze early heart development in the zebrafish. Specifically, I am analyzing the process in which the "volcano" shaped heart precursor forms the heart tube. This process amounts to telescoping of the relatively flat volcano to the heart tube which can be modeled as a continuum.

Nick
Nicholas F.C. Morante

Research Interest: Cilia are some of the first organelles ever described, but the full extent of their roles in vertebrate development and human disease have only recently begun to surface. Motile cilia, which serve roles in generating fluid flow across epithelia, were found to be critical for establishing correct left-right asymmetry, but have recently been shown to have a cryptic function in maintain straightness of the body axis in fish and, potentially, humans. I study forward and reverse cilia mutants by mapping and reverse genetics in order to get a more full picture of the spectrum of functions that motile cilia serve in vertebrate development.

Aleena Patel
Aleena L. Patel

Research Interest: I am currently developing optogenetic tools to study signaling pathways in the developing zebrafish embryo.  My work is motivated by an interest in gaining a quantitative understanding of the signaling involved in cell fate induction during development.  My research will primarily focus on understanding early hindbrain patterning.  

Jose 
José Pelliccia
Email José

Research Interest: I am examining the regulation ofcharonin KV, specifically at the genomic level, by identifying transcription factors and regulatory elements that play a role incharonexpression. From there, I can characterize which of these factors/elements are required for patterning and morphogenesis in relation tocharon versus those which may play a role in other possiblec haron functionalities.

Undergraduate Students

Briana Christophers

Briana Christophers '17
Email Bri

Research Interest: My research aims to create a model for cardiac looping, a conserved process in vertebrate heart development that places the heart chambers in their final position, by studying the function of FGF signaling. Early experiments implicate FGF signaling as being important for directing cell migration/accretion during early heart morphogenesis and for proper chamber development and cardiac looping. Current results are consistent with studies done in chick and mice in other laboratories, suggesting that even the intricacies of heart development in vertebrates may be similar enough to provide insights about what may be occurring in human congenital heart defects. 

Marvin Cortez
Marvin Cortez 

Research Interest: Hi, my name is Marvin Cortez. I am a visiting undergraduate student from the University of California, Irvine. I work with Jose in investigating the regulatory mechanisms behind dand5 asymmetry as well as pkd2 localization to cilia and its role in left-right asymmetry. 

Joshua Morrison
Joshua Morrison '17

Research Interest: I'm working on developing an in vivo characterization of podosomes in the context of heart morphogenesis. Podosomes are known to play roles in embryogenesis and tumor metastasis; however, it is relatively unknown how they do so and how they are regulated in vivo. My goal is to begin working on a model for how podosomes are formed and regulated, as well as how they affect cardiomyocyte migration during heart formation in zebrafish. 

Administrative Support

 
Laisa Eimont
Faculty Assistant

Lab Mascot

 
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TGF (get it?)